Oprah Winfrey's Transformative Weight Loss Journey

A series of three images showcasing a woman’s weight loss and style evolution over the years, from a gold and yellow outfit to elegant purple gowns
Pooja Shinde
Medically Reviewed
Pooja Shinde
Team lead - Health Coach
March 31, 2025

Oprah Winfrey, a global media icon, has long been candid about her struggles with weight and the societal pressures accompanying it. Recently, at the age of 70, she has undergone a significant transformation, shed approximately 40 pounds and redefined her approach to health and wellness. This journey intertwines physical activity, mindful eating, medical intervention, and a profound shift in mental and emotional well-being.​

Motivation Behind the Weight Loss

For decades, Oprah grappled with fluctuating weight, often under the public's scrutinizing eye. The turning point came after a knee surgery in 2021, which ignited her commitment to a healthier lifestyle. She began hiking regularly, setting incremental distance goals that not only aided in weight loss but also enhanced her overall vitality. Reflecting on this period,
Oprah expressed feeling "stronger, more fit, and more alive than I’d felt in years."

Incorporation of Mounjaro

Oprah incorporated medical intervention into her weight loss strategy. She began using a prescription weight-loss medication as a "maintenance tool" to manage her weight effectively. While she has not publicly specified the exact medication, drugs like Mounjaro have gained prominence for their efficacy in weight management. Oprah expressed relief and empowerment in utilizing medical aids, stating, "The fact that there's a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift."

Understanding Mounjaro

Mounjaro (tirzepatide) is a medication developed by Eli Lilly for the treatment of type 2 diabetes. It functions by mimicking hormones that regulate blood sugar and appetite, thereby aiding in weight loss. Clinical trials have demonstrated significant weight reduction in individuals using Mounjaro, making it a promising option for those struggling with obesity. However, like all medications, it may have side effects, and its use should be under the guidance of a healthcare professional.

Dietary Approach

Oprah adopted a structured dietary regimen to support her weight loss goals. Key components of her diet include:​

Exercise Routine

Complementing her dietary changes, Oprah incorporated a consistent exercise routine into her daily life. The following table outlines her weekly workout schedule:​

Day

Activity

Duration/Distance

Monday

Hiking

3-5 miles

Tuesday

Running

Variable

Wednesday

Weight Resistance Training

1 hour

Thursday

Hiking

3-5 miles

Friday

Running

Variable

Saturday

10-mile Uphill Hike

10 miles

Sunday

Rest or Light Activity

As desired

This regimen reflects her dedication to building strength and endurance, with activities tailored to her recovery and fitness levels. ​

Mental and Emotional Well-being

Throughout her weight loss journey, Oprah confronted and addressed the psychological aspects of obesity. She recognized that obesity is not solely a matter of willpower but involves complex factors, including brain chemistry. This realization led her to release self-blame and embrace a more compassionate perspective towards herself and others facing similar challenges. Oprah emphasized the importance of shedding the stigma associated with weight issues, stating, "I come to this conversation in the hope that we can start releasing the stigma and the shame and the judgment... to stop shaming other people for being overweight or how they chose to lose and not lose weight."

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Disclaimer: The information provided in this blog is for general informational purposes only and is compiled from publicly available sources. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Reliance on any information provided in this blog is solely at your own risk. We do not guarantee the accuracy, completeness, or usefulness of this information.

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